Glutathoine is the mother of all antioxidants and as it depletes we are looking for more and more ways to keep and maintain the levels. When the levels go down too much, studies have shown that this leads to inflammation and oxidation within the cells of our body.
What Is Glutathione?
Glutathione is a small protein molecule composed of the amino acids glutamate, cysteine, and glycine. Its the most important antioxidant found in every single cell in the human body and living organisms.
GLUTATHIONE BENEFITS FOR HEALTH
What Does Glutathione Do?
Glutathione helps protect our cells from damage as well as aids in detoxifying harmful compounds.
Over the course of 100 years of research, more than 100,000 scientific papers have established maintaining cellular glutathione levels as one of the most important keys in maintaining proper cellular function, immune health, and slowing the aging process.
5 Benefits of Glutathione
- It is an antioxidant. Glutathione is the cell’s major antioxidant to protect the cell from damage. It is also critical to the recycling and proper utilization of other antioxidants such as Vitamin Cvand E.
- It has immune system effects. Glutathione protects immune cells from damage while also exerting some direct antiviral effects. It is also critical in modulating balance within the immune system. It boosts functions when the immune system is underactive and brings it back into balance when it is overactive.
- It has mitochondrial effects. Glutathione plays a critical role in the function of mitochondria (the energy-producing compartments in cells).
- It is critical to cellular function. Glutathione is required for the manufacture of many cellular proteins, the synthesis and repair of DNA, the activation and regulation of cellular enzymes involved in overall cell function, and the proper action of vitamin D3.
- It is a detoxifying compound. Glutathione is the body's most effective detoxifying agent. Glutathione binds undesirable toxins, pollutants, chemicals, heavy metals, and drug metabolites and excretes them through the urine or the gut.
What Happens When Glutathione Levels in the Body are Low?
Glutathione levels tend to drop as we age, as well as when we are exposed to toxins, drugs, environmental pollution, and any other compound that causes oxidative damage. Even something as simple as taking acetaminophen (e.g., Tylenol) can cause glutathione levels to plummet. Low levels of glutathione are linked to accelerated aging and almost every chronic disease, especially those associated with aging like cognitive decline, type 2 diabetes, and many forms of chronic disease.
Being older is a well-recognized risk factor for severe illness, complications, and death from a variety of causes including viral infections. Lower glutathione levels make cells more susceptible to oxidative damage. Low glutathione levels can also impair the immune system as well as the protective barriers in the respiratory and gastrointestinal tract.
The same impairments exist in these conditions:
- Chronic kidney disease
- COPD (chronic obstructive pulmonary disease)
- Immuno compromised state (weakened immune system) from solid organ transplant
- Obesity (body mass index [BMI] of 30 or higher)
- Serious heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies
- Sickle cell disease
- Type 2 diabetes mellitus
What Role Does Glutathione Play in Immune Function?
During this time of increased focus on immune health, it is important to understand how important glutathione is in protecting against infections. What the research is quite clear on is that higher cellular levels of glutathione are associated with a person having the proper response to viral infections. This effect is due to glutathione protecting immune cells from damage as well as enhancing immune functions that are critical to protecting against viruses.4 Glutathione has also shown direct effects in blocking the replication of various viruses at different stages of its life cycle.5 These antiviral properties of glutathione are thought to help prevent increased viral loads and the subsequent massive release of inflammatory cells into the lungs seen with certain viral illnesses.
What Dietary Factors and Supplements Boost Glutathione Levels?
Diet can help raise glutathione levels, but only to a limited extent. The human body, mainly the liver, makes about 8,000 to 10,000 mg of glutathione daily. To put this amount into perspective, a healthy diet rich in fresh fruit and vegetables may provide about 150 mg of preformed glutathione per day. That said, the cell strives to hang on to glutathione so the cumulative effects of higher dietary glutathione intake are certainly an important goal. Asparagus, avocado, and walnuts are particularly rich dietary sources of glutathione.
The most popular supplemental approaches to boost glutathione levels involve taking either glutathione or N-Acetylcysteine. Prior to recent studies, there was some controversy with glutathione as a dietary supplement because it was thought that glutathione may not be absorbed when taken orally. One early study is often cited to show a lack of absorption. In the study, a single dose of 3,000 mg of glutathione failed to increase glutathione levels in the blood. However, it turns out there is another reason.7 Researchers were looking for free glutathione levels and because glutathione is so valuable it is quickly bound to transport proteins to carry to cells causing it to not show up as free glutathione in the blood.
Can Glutathione Supplements Be Absorbed Orally?
The first study showing significant oral absorption in humans with reduced glutathione (GSH) was conducted at Kyoto University in 2014. The study was different because it looked not only at free, unbound glutathione in the blood, but also the level of glutathione bound to protein. The results showed that while there was no significant difference in free glutathione levels, the level of glutathione bound to protein increased significantly after glutathione supplementation. This study was groundbreaking because it explained the shortcomings of previous absorption studies.
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DISCLAIMER: "This is for educational purposes only and information on this blog is not intended for any type of medical advice. Always consult a Doctor before taking any supplements"
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